Pathway Tools Tip

Green "?" Buttons Provide Help

Click on the small help buttons containing a "?" within a green circle for explanations of nearby elements of a page

To unsubscribe from tips, login or create an account.

Synonyms: endoribonuclease IV, poly(A)-specific ribonuclease

Unification Links: BRENDA:3.1.26.6, ENZYME:3.1.26.6, IUBMB-ExplorEnz:3.1.26.6

Reaction:
poly(A) tail + H₂O → n a double-stranded oligonucleotide

Summary:
This enzyme catalyzes endonucleolytic cleavage of poly(A) to fragments terminated by 3-hydroxy and 5-phosphate groups.

Forms oligonucleotides with an average chain length of 10.

Citations: [Muller76, Muller76a]

References

Muller76: Muller WE (1976). "Endoribonuclease IV. A poly(A)-specific ribonuclease from chick oviduct. 1. Purification of the enzyme." Eur J Biochem 70(1);241-8. PMID: 1009928

Muller76a: Muller WE, Seibert G, Steffen R, Zahn RK (1976). "Endoribonuclease IV. 2. Further investigation on the specificity." Eur J Biochem 70(1);249-58. PMID: 1009929