Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.1 -- Acting on ester bonds → 3.1.1 -- Carboxylic ester hydrolases

Synonyms: mycophenolic acid acyl-glucuronide deglucuronidase, AcMPAG deglucuronidase

Systematic Name: mycophenolic acid O-acyl-glucuronide-ester hydrolase

Unification Links: BRENDA:3.1.1.93, ENZYME:3.1.1.93, IUBMB-ExplorEnz:3.1.1.93

Reaction:
mycophenolic acid O-acyl-glucuronide + H₂O → mycophenolate + D-glucopyranuronate + H⁺

Enzymes and Genes:
mycophenolic acid acyl-glucuronide esterase: ABHD10 ( Homo sapiens )

Summary:
This liver enzyme deglucuronidates mycophenolic acid O-acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate, which is thought to be immunotoxic.

Citations: [Iwamura12]

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References

Iwamura12: Iwamura A, Fukami T, Higuchi R, Nakajima M, Yokoi T (2012). "Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver." J Biol Chem 287(12);9240-9. PMID: 22294686

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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