Parent Class:

EC-Numbers → 2 -- Transferases → 2.7 -- Transferring phosphorous-containing groups → 2.7.1 -- Phosphotransferases with an alcohol group as acceptor

Synonyms: ketohexokinase (phosphorylating)

Systematic Name: ATP:D-fructose 1-phosphotransferase

Unification Links: BRENDA:2.7.1.3, ENZYME:2.7.1.3, IUBMB-ExplorEnz:2.7.1.3

Reaction:
β-D-fructofuranose + ATP → β-D-fructofuranose 1-phosphate + ADP + H⁺

Enzymes and Genes:
ketohexokinase: KHK ( Homo sapiens )

Summary:
D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates [Raushel77].

Citations: [Cori51, Hers52, Parks57]

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References

Cori51: Cori GT, Ochoa S, Slein MW, Cori CF (1951). "The metabolism of fructose in liver; isolation of fructose-I-phosphate and inorganic pyrophosphate." Biochim Biophys Acta 7(2);304-17. PMID: 14858418

Hers52: Hers HG (1952). "[Liver fructokinase]." Biochim Biophys Acta 8(4);416-23. PMID: 13208667

Parks57: Parks RE, Ben-Gershom E, Lardy HA (1957). "Liver fructokinase." J Biol Chem 227(1);231-42. PMID: 13449068

Raushel77: Raushel FM, Cleland WW (1977). "Bovine liver fructokinase: purification and kinetic properties." Biochemistry 16(10);2169-75. PMID: 193556

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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