Parent Class:

EC-Numbers → 2 -- Transferases → 2.7 -- Transferring phosphorous-containing groups → 2.7.1 -- Phosphotransferases with an alcohol group as acceptor

Synonyms: Fn3KRP, FN3K-related protein, FN3K-RP, ketosamine 3-kinase 2, fructosamine-3-kinase-related protein, ribulosamine/erythrulosamine 3-kinase, ribulosamine 3-kinase

Systematic Name: ATP:[protein]-N⁶-D-ribulosyl-L-lysine 3-phosphotransferase

Unification Links: BRENDA:2.7.1.172, ENZYME:2.7.1.172, IUBMB-ExplorEnz:2.7.1.172

Reaction:
[protein]-N⁶-D-ribulosyl-L-lysine + ATP → [protein]-N⁶-(3-O-phospho-D-ribulosyl)-L-lysine + ADP + H⁺

Enzymes and Genes:
ribulosamine-3-kinase: FN3KRP ( Homo sapiens )

Summary:
This enzyme plays a role in freeing proteins from ribulosamines or psicosamines, which might arise from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by protein-fructosamine 3-kinase ( EC 2.7.1.171), which has, in addition, the unique capacity to phosphorylate fructosamines [Collard03]. The plant enzyme also phosphorylates [protein]-N6-D-erythrulosyl-L-lysine [Fortpied05]. No activity with [protein]-N6-D-fructosyl-L-lysine [Collard03, Fortpied05].

Citations: [Payne08]

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References

Collard03: Collard F, Delpierre G, Stroobant V, Matthijs G, Van Schaftingen E (2003). "A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines." Diabetes 52(12);2888-95. PMID: 14633848

Fortpied05: Fortpied J, Gemayel R, Stroobant V, van Schaftingen E (2005). "Plant ribulosamine/erythrulosamine 3-kinase, a putative protein-repair enzyme." Biochem J 388(Pt 3);795-802. PMID: 15705060

Payne08: Payne LS, Brown PM, Middleditch M, Baker E, Cooper GJ, Loomes KM (2008). "Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine." Biochem J 416(2);281-8. PMID: 18637789

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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