Parent Class:

EC-Numbers → 2 -- Transferases → 2.5 -- Transferring alkyl or aryl groups, other than methyl groups → 2.5.1 -- Transferring alkyl or aryl groups, other than methyl groups

Synonyms: HexPS(ambiguous), (all-E) hexaprenyl diphosphate synthase, (all-trans) hexaprenyl diphosphate synthase, hexaprenyl pyrophosphate synthase (ambiguous), HexPPs (ambiguous), hexaprenyl diphosphate synthase (ambiguous)

Systematic Name: geranylgeranyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate transferase (adding 2 units of 3-methylbut-3-en-1-yl)

Unification Links: BRENDA:2.5.1.82, ENZYME:2.5.1.82, IUBMB-ExplorEnz:2.5.1.82

Supersedes EC number: 2.5.1.33

Reaction:
geranylgeranyl diphosphate + 2 isopentenyl diphosphate → all-trans-hexaprenyl diphosphate + 2 diphosphate

Enzymes and Genes:
geranylgeranyl-diphosphate hexaprenyl diphosphate synthase: gdS-2 ( Saccharolobus solfataricus )

Summary:
The enzyme prefers geranylgeranyl diphosphate to (2E,6E)-farnesyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate. Requires Mg²⁺ [Hemmi02].

Citations: [Hemmi02a, Sun05]

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References

Hemmi02: Hemmi H, Ikejiri S, Yamashita S, Nishino T (2002). "Novel medium-chain prenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus." J Bacteriol 184(3);615-20. PMID: 11790729

Hemmi02a: Hemmi H, Noike M, Nakayama T, Nishino T (2002). "Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations." Biochem Biophys Res Commun 297(5);1096-101. PMID: 12372398

Sun05: Sun HY, Ko TP, Kuo CJ, Guo RT, Chou CC, Liang PH, Wang AH (2005). "Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures." J Bacteriol 187(23);8137-48. PMID: 16291686

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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