Parent Class:

EC-Numbers → 2 -- Transferases → 2.4 -- Glycosyltransferases → 2.4.2 -- Pentosyltransferases

Synonyms: 5-phospho-α-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase, 5-phospho-α-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase, DPPR synthase, Rv3806

Systematic Name: trans,octacis-decaprenylphospho-β-D-ribofuranose 5-phosphate:diphosphate phospho-α-D-ribosyltransferase

Unification Links: BRENDA:2.4.2.45, ENZYME:2.4.2.45, IUBMB-ExplorEnz:2.4.2.45

Reaction:
5-phospho-α-D-ribose 1-diphosphate + trans,octacis-decaprenyl phosphate + H⁺ → trans,octacis-decaprenylphospho-β-D-ribofuranose 5-phosphate + diphosphate

Enzymes and Genes:
DPPR synthase: ubiA ( Mycobacterium tuberculosis H37Rv )

Summary:
Requires Mg²⁺. Isolated from Mycobacterium tuberculosis. Has some activity with other polyprenyl phosphates.

Citations: [Huang05a, Makarov09]

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References

Huang05a: Huang H, Scherman MS, D'Haeze W, Vereecke D, Holsters M, Crick DC, McNeil MR (2005). "Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis." J Biol Chem 280(26);24539-43. PMID: 15878857

Makarov09: Makarov V, Manina G, Mikusova K, Mollmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST (2009). "Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis." Science 324(5928);801-4. PMID: 19299584

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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