Pathway Tools Tip

Green "?" Buttons Provide Help

Click on the small help buttons containing a "?" within a green circle for explanations of nearby elements of a page

Parent Class:

EC-Numbers → 2 -- Transferases → 2.4 -- Glycosyltransferases → 2.4.1 -- Hexosyltransferases

Synonyms: GDP-L-Fuc:N-acetyl-β-D-glucosaminide α1,3-fucosyltransferase, GDP-L-Fuc:Asn-linked GlcNAc α1,3-fucosyltransferase, GDP-fucose:β-N-acetylglucosamine (Fuc to (Fucα1→6GlcNAc)-Asn-peptide) α1→3-fucosyltransferase, GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine) 3-α-L-fucosyl-transferase, GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N⁴-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine) 3-α-L-fucosyl-transferase, GDP-β-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N⁴-{N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→3)-[N-acetyl-β-D-glucosaminyl-(1→2)-α-D-mannosyl-(1→6)]-β-D-mannosyl-(1→4)-N-acetyl-β-D-glucosaminyl-(1→4)-N-acetyl-β-D-glucosaminyl}asparagine) 3-α-L-fucosyl-transferase

Systematic Name: GDP-β-L-fucose:N⁴-{β-D-GlcNAc-(1→2)-α-D-Man-(1→3)-[β-D-GlcNAc-(1→2)-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc}-L-asparaginyl-[protein] 3-α-L-fucosyltransferase (configuration-retaining)

Unification Links: BRENDA:2.4.1.214, ENZYME:2.4.1.214, IUBMB-ExplorEnz:2.4.1.214

Reaction:
GDP-β-L-fucose + Man₃(GlcNAc)₄-[protein] → a β-D-GlcNAc-(1→2)-α-D-Man-(1→3)-[β-D-GlcNAc-(1→2)-α-D-Man-(1→6)]-[β-D-Xyl-(1→2)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc}-N-Asn-[protein] + GDP + H⁺

Unofficial Reactions:
GDP-β-L-fucose + β-D-GlcNAc-(1→2)-α-D-Man-(1→3)-[β-D-GlcNAc-(1→2)-α-D-Man-(1→6)]-[β-D-Xyl-(1→2)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc}-N-Asn-[protein] → β-D-GlcNAc-(1→2)-α-D-Man-(1→3)-[β-D-GlcNAc-(1→2)-α-D-Man-(1→6)]-[β-D-Xyl-(1→2)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-[α-L-Fuc-(1→3)]-β-D-GlcNAc}-N-Asn-[protein] + GDP + H⁺

Enzymes and Genes:
glycoprotein 3-α-L-fucosyltransferase FUT12: FUT12 ( Arabidopsis thaliana )
glycoprotein 3-α-L-fucosyltransferase FUT11: FUT11 ( Arabidopsis thaliana )

Summary:
The enzyme transfers to N-linked oligosaccharide structures (N-glycans), generally with a specificity for N-glycans with one unsubstituted non-reducing terminal GlcNAc residue. This enzyme catalyzes a reaction similar to that of EC 2.4.1.68, glycoprotein 6-α-L-fucosyltransferase, but transferring the L-fucosyl group from GDP-beta-L-fucose to form an alpha-1,3-linkage rather than an alpha-1,6-linkage. The N-glycan products of this enzyme are present in plants, insects and some other invertebrates (e.g., Schistosoma, Haemonchus, Lymnaea).

Citations: [Staudacher91, vanTetering99, Leiter99, Fabini01, Wilson01]