MetaCyc

Parent Class:

EC-Numbers → 2 -- Transferases → 2.4 -- Glycosyltransferases → 2.4.1 -- Hexosyltransferases

Synonyms: UDP-glucose—glucose-phosphate glucosyltransferase, trehalosephosphate-UDP glucosyltransferase, UDP-glucose-glucose-phosphate glucosyltransferase, α,α-trehalose phosphate synthase (UDP-forming), phosphotrehalose-uridine diphosphate transglucosylase, trehalose 6-phosphate synthase, trehalose 6-phosphate synthetase, trehalose phosphate synthase, trehalose phosphate synthetase, trehalose phosphate-uridine diphosphate glucosyltransferase, trehalose-P synthetase, transglucosylase, uridine diphosphoglucose phosphate glucosyltransferase, UDP-glucose:D-glucose-6-phosphate 1-α-D-glucosyltransferase

Systematic Name: UDP-α-D-glucose:D-glucose-6-phosphate 1-α-D-glucosyltransferase (configuration-retaining)

Unification Links: BRENDA:2.4.1.15, ENZYME:2.4.1.15, IUBMB-ExplorEnz:2.4.1.15

Reaction:
UDP-α-D-glucose + D-glucopyranose 6-phosphate → α,α-trehalose 6-phosphate + UDP + H⁺

Enzymes and Genes:
trehalose-6-phosphate synthase: otsA ( Escherichia coli K-12 substr. MG1655 )
trehalose synthase complex: TPS1, TPS2, TSL1, TPS3 ( Saccharomyces cerevisiae )
trehalose-6-phosphate synthase: TPS-1 ( Helicoverpa armigera )
α,α-trehalose-phosphate synthase (ADP-forming): otsA ( Mycolicibacterium smegmatis )
trehalose-6-phosphate synthase ( Halorhodospira halochloris )
trehalose-6-phosphate synthase: TPS1 ( Saccharomyces cerevisiae )

Summary:
The enzyme contributes to stationary phase survival of Saccharomyces cerevisiae by elevating the levels of the intercellular stress sugar α,α-trehalose in the cell as it enters the stationary phase. See also EC 2.4.1.36, α,α-trehalose-phosphate synthase (GDP-forming).

Citations: [Cabib58, Candy61, Lornitzo64, Murphy65]