Parent Class:

EC-Numbers → 2 -- Transferases → 2.3 -- Acyltransferases → 2.3.1 -- Transferring groups other than amino-acyl groups

Synonyms: polyketide synthase A (ambiguous), PksA (ambiguous), norsolorinic acid anthrone synthase

Systematic Name: malonyl-CoA:hexanoate malonyltransferase (norsolorinic acid anthrone-forming)

Unification Links: BRENDA:2.3.1.221, ENZYME:2.3.1.221, IUBMB-ExplorEnz:2.3.1.221

Reaction:
hexanoyl-[acp] + 7 malonyl-CoA + 5 H⁺ → norsolorinate anthrone + acyl-carrier protein + 7 coenzyme A + 7 CO₂ + 2 H₂O

Enzymes and Genes:
norsolorinate anthrone synthase: aflC ( Aspergillus parasiticus )

Summary:
A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase [Crawford08].

Citations: [Crawford09, Korman10]

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References

Crawford08: Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA (2008). "Deconstruction of iterative multidomain polyketide synthase function." Science 320(5873);243-6. PMID: 18403714

Crawford09: Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA (2009). "Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization." Nature 461(7267);1139-43. PMID: 19847268

Korman10: Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC (2010). "Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis." Proc Natl Acad Sci U S A 107(14);6246-51. PMID: 20332208

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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