Parent Class:

EC-Numbers → 2 -- Transferases → 2.3 -- Acyltransferases → 2.3.1 -- Transferring groups other than amino-acyl groups

Synonyms: pseudotropine:acyl-CoA transferase, tigloyl-CoA:pseudotropine acyltransferase, acetyl-CoA:pseudotropine acyltransferase, pseudotropine acetyltransferase, pseudotropine tigloyltransferase, PAT (ambiguous)

Systematic Name: acyl-CoA:pseudotropine O-acyltransferase

Unification Links: BRENDA:2.3.1.186, ENZYME:2.3.1.186, IUBMB-ExplorEnz:2.3.1.186

Reaction:
an acyl-CoA + pseudotropine → an O-acylpseudotropine + coenzyme A

Summary:
This enzyme exhibits absolute specificity for the exo/3β configuration found in pseudotropine as tropine (see EC 2.3.1.185, tropine acyltransferase) and nortropine are not substrates. Acts on a wide range of aliphatic acyl-CoA derivatives, including acetyl-CoA, 3-methylcrotonyl-CoA and (E)-2-methylcrotonoyl-CoA.

Citations: [Robins91, Boswell99]

---

References

Boswell99: Boswell HD, Drager B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ (1999). "Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura." Phytochemistry 52(5);871-8. PMID: 10626376

Robins91: Robins RJ, Bachmann P, Robinson T, Rhodes MJ, Yamada Y (1991). "The formation of 3 alpha- and 3 beta-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases." FEBS Lett 292(1-2);293-7. PMID: 1959620

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.5 (software by SRI International) on Sat Mar 29, 2025, BIOCYC18B.