MetaCyc

Parent Class:

EC-Numbers → 2 -- Transferases → 2.3 -- Acyltransferases → 2.3.1 -- Transferring groups other than amino-acyl groups

Synonyms: SCP2 (gene name), peroxisomal thiolase 2, sterol carrier protein-χ, SCP_χ, PTE-2 (ambiguous), propionyl-CoA C²-trimethyltridecanoyltransferase, 3-oxopristanoyl-CoA hydrolase, 3-oxopristanoyl-CoA thiolase, peroxisome sterol carrier protein thiolase, sterol carrier protein, oxopristanoyl-CoA thiolase, peroxisomal 3-oxoacyl coenzyme A thiolase, SCPx, 4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase

Systematic Name: 3α,7α,12α-trihydroxy-5β-cholanoyl-CoA:propanoyl-CoA C-acyltransferase

Unification Links: BRENDA:2.3.1.176, ENZYME:2.3.1.176, IUBMB-ExplorEnz:2.3.1.176

Supersedes EC number: 2.3.1.154

Reaction:
choloyl-CoA + propanoyl-CoA ← coenzyme A + 3α,7α,12α-trihydroxy-24-oxo-5-β-cholestanoyl CoA

Unofficial Reactions:
chenodeoxycholoyl-CoA + propanoyl-CoA ← 3α,7α-dihydroxy-24-oxo-5β-cholestanoyl CoA + coenzyme A,
3-oxochol-4-en-24-oyl-CoA + propanoyl-CoA ← 3,24-dioxocholest-4-en-26-oyl-CoA + coenzyme A,
4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA ← coenzyme A + 3-oxopristanoyl-CoA

Enzymes and Genes:
sterol carrier protein 2: Scp2 ( Rattus norvegicus )

Summary:
Also acts on dihydroxy-5-beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. Catalyzes the penultimate step in the formation of bile acids. The bile acid moiety is transferred from the acyl-CoA thioester (RCO SCoA) to either glycine or taurine (NH(2)R') by EC 2.3.1.65, bile acid-CoA:amino acid N-acyltransferase [Falany94].

Citations: [Pedersen80, Kase83, Russell03]