Parent Class:

EC-Numbers → 2 -- Transferases → 2.3 -- Acyltransferases → 2.3.1 -- Transferring groups other than amino-acyl groups

Synonyms: α-glycerophosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerophosphate acyltransferase, glycerophosphate transacylase, sn-glycerol 3-phosphate acyltransferase, sn-glycerol-3-phosphate acyltransferase, glycerol-3-phosphate O-acyltransferase (ambiguous)

Systematic Name: acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

Unification Links: BRENDA:2.3.1.15, ENZYME:2.3.1.15, IUBMB-ExplorEnz:2.3.1.15

Reaction:
an acyl-CoA + sn-glycerol 3-phosphate → a 2-lysophosphatidate + coenzyme A

Unofficial Reactions:
myristoyl-[acp] + sn-glycerol 3-phosphate → 1-myristoyl-sn-glycerol 3-phosphate + acyl-carrier protein,
arachidonoyl-CoA + sn-glycerol 3-phosphate → 1-arachidinoyl-sn-glycerol 3-phosphate + coenzyme A,
oleoyl-CoA + sn-glycerol 3-phosphate → 1-oleoyl-sn-glycerol 3-phosphate + coenzyme A,
cis-vaccenoyl-[acp] + sn-glycerol 3-phosphate → 1-cis-vaccenoyl-sn-glycerol-3-phosphate + acyl-carrier protein,
hexadecanedioyl-CoA + sn-glycerol 3-phosphate → coenzyme A + 1-C16:0-α,ω-dicarboxyl-2-lysophosphatidate,
18-hydroxyoleoyl-CoA + sn-glycerol 3-phosphate → 1-(18-hydroxyoleoyl)-sn-glycrol 3-phosphate + coenzyme A,
palmitoyl-[acp] + sn-glycerol 3-phosphate → 1-palmitoyl-sn-glycerol 3-phosphate + acyl-carrier protein,
acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate → a 2-lysophosphatidate + acyl-carrier protein,
palmitoyl-CoA + sn-glycerol 3-phosphate → 1-palmitoyl-sn-glycerol 3-phosphate + coenzyme A,
stearoyl-[acp] + sn-glycerol 3-phosphate → 1-stearoyl-sn-glycerol 3-phosphate + acyl-carrier protein

Enzymes and Genes:
bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase: GPT2 ( Saccharomyces cerevisiae )
bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase: SCT1 ( Saccharomyces cerevisiae )
glycerol-3-phosphate O-acyltransferase GPAT9: GPAT9 ( Arabidopsis thaliana col )
glycerol 3-phosphate acyltransferase 1: GPAM ( Homo sapiens )
glycerol-3-phosphate 1-O-acyltransferase: plsB ( Escherichia coli K-12 substr. MG1655 )

Summary:
Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme acts only on derivatives of fatty acids of chain length above C10.

Citations: [Yamashita72, Bertrams81, Frentzen83, Green83]

---

References

Bertrams81: Bertrams M, Heinz E (1981). "Positional Specificity and Fatty Acid Selectivity of Purified sn-Glycerol 3-Phosphate Acyltransferases from Chloroplasts." Plant Physiol 68(3);653-7. PMID: 16661974

Frentzen83: Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts." Eur J Biochem 129(3);629-36. PMID: 6825679

Green83: Green PR, Vanaman TC, Modrich P, Bell RM (1983). "Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase." J Biol Chem 258(18);10862-6. PMID: 6350296

Yamashita72: Yamashita S, Numa S (1972). "Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation of 1-acylglycerol 3-phosphate from sn-glycerol 3-phosphate and palmityl coenzyme A." Eur J Biochem 31(3);565-73. PMID: 4650158

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.5 (software by SRI International) on Sat Mar 29, 2025, BIOCYC16A.