Parent Class:

EC-Numbers → 2 -- Transferases → 2.1 -- Transferring one-carbon groups → 2.1.1 -- Methyltransferases

Synonyms: messenger ribonucleate guanine 7-methyltransferase, guanine-7-methyltransferase, messenger RNA guanine 7-methyltransferase, S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase

Systematic Name: S-adenosyl-L-methionine:mRNA (guanine-N⁷)-methyltransferase

Unification Links: BRENDA:2.1.1.56, ENZYME:2.1.1.56, IUBMB-ExplorEnz:2.1.1.56

Reaction:
S-adenosyl-L-methionine + 5'-(5'-triphosphoguanosine)-(nucleotide)-[mRNA] → S-adenosyl-L-homocysteine + 5'-(N⁷-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA]

Enzymes and Genes:
mRNA cap guanine-N7 methyltransferase: RNMT ( Homo sapiens )
mRNA (guanine-N⁷)-methyltransferase: ABD1 ( Saccharomyces cerevisiae )

Summary:
The terminal N⁷-methylguanosine facilitates gene expression in eukaryotic cells and is recognized by cap-binding proteins.

Citations: [Ensinger75, Martin75, Martin75a, Groner78]

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References

Ensinger75: Ensinger MJ, Martin SA, Paoletti E, Moss B (1975). "Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus." Proc Natl Acad Sci U S A 72(7);2525-9. PMID: 1058472

Groner78: Groner Y, Gilboa E, Aviv H (1978). "Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates." Biochemistry 17(6);977-82. PMID: 629955

Martin75: Martin SA, Moss B (1975). "Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions." J Biol Chem 250(24);9330-5. PMID: 1194287

Martin75a: Martin SA, Paoletti E, Moss B (1975). "Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions." J Biol Chem 250(24);9322-9. PMID: 1194286

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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