Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.8 -- Acting on a sulfur group of donors → 1.8.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: mycothiol-disulfide reductase

Systematic Name: mycothiol:NAD(P)⁺ oxidoreductase

Unification Links: BRENDA:1.8.1.15, ENZYME:1.8.1.15, IUBMB-ExplorEnz:1.8.1.15

Reaction:
2 mycothiol + NAD(P)⁺ ← mycothione + NAD(P)H + H⁺

Enzymes and Genes:
mycothione reductase: mtr ( Corynebacterium glutamicum ATCC 13032 )
mycothione reductase: gorA ( Mycobacterium tuberculosis H37Rv )

Summary:
No activity with glutathione, trypanothione or coenzyme A as substrate.

Citations: [Patel99, Patel01]

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References

Patel01: Patel MP, Blanchard JS (2001). "Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects." Biochemistry 40(17);5119-26. PMID: 11318633

Patel99: Patel MP, Blanchard JS (1999). "Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase." Biochemistry 38(36);11827-33. PMID: 10512639

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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