Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.5 -- Acting on the CH-NH group of donors → 1.5.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: easG (gene name)

Systematic Name: agroclavine:NADP⁺ oxidoreductase

Unification Links: BRENDA:1.5.1.46, ENZYME:1.5.1.46, IUBMB-ExplorEnz:1.5.1.46

Reaction:
agroclavine + NADP⁺ ← 6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH + H⁺

Enzymes and Genes:
agroclavine dehydrogenase: easG ( Claviceps purpurea )

Summary:
The enzyme participates in the biosynthesis of ergotamine, an ergot alkaloid produced by some fungi of the Clavicipitaceae family. The reaction is catalysed in the opposite direction to that shown. The substrate for the enzyme is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione.

Citations: [Matuschek11]

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References

Matuschek11: Matuschek M, Wallwey C, Xie X, Li SM (2011). "New insights into ergot alkaloid biosynthesis in Claviceps purpurea: an agroclavine synthase EasG catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-I aldehyde to agroclavine." Org Biomol Chem 9(11);4328-35. PMID: 21494745

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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