Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.3 -- Acting on the CH-CH group of donors → 1.3.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: TSC13 (gene name), CER10 (gene name)

Systematic Name: very-long-chain acyl-CoA:NADP⁺ oxidoreductase

Unification Links: BRENDA:1.3.1.93, ENZYME:1.3.1.93, IUBMB-ExplorEnz:1.3.1.93

Supersedes EC number: 2.3.1.119

Reaction:
a very-long-chain 2,3,4-saturated fatty acyl CoA + NADP⁺ ← a very-long-chain (2E)-2-enoyl-CoA + NADPH + H⁺

Unofficial Reactions:
(11Z,14Z)-icosadienoyl-CoA + NADP⁺ ← (2E,11Z,14Z)-icosa-2,11,14-trienoyl-CoA + NADPH + H⁺,
auricoloyl-CoA + NADP⁺ ← (2E,11Z,14R,17Z)-14-hydroxy-icosa-2,11,17-trienoyl-CoA + NADPH + H⁺,
docosanoyl-CoA + NADP⁺ ← trans-docos-2-enoyl-CoA + NADPH + H⁺,
arachidoyl-CoA + NADP⁺ ← (2E)-icos-2-enoyl-CoA + NADPH + H⁺,
(2E,8Z,11Z,14Z)-icosatetraenoyl-CoA + NADH + H⁺ → dihomo γ-linolenoyl-CoA + NAD⁺,
octacosanoyl-CoA + NADP⁺ ← trans-octacos-2-enoyl-CoA + NADPH + H⁺,
(15Z)-tetracosenoyl-CoA + NADP⁺ ← (2E,15Z)-tetracos-2,15-dienoyl-CoA + NADPH + H⁺,
tetratriacontanoyl-CoA + NADP⁺ ← trans-tetratriaconta-2-enoyl-CoA + NADPH + H⁺,
lignoceroyl-CoA + NADP⁺ ← trans-lignocer-2-enoyl-CoA + NADPH + H⁺,
(2E,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA + reduced two electron carrier → (8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA + oxidized electron carrier,
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADP⁺ ← (2E,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NADPH + H⁺,
dotriacontanoyl-CoA + NADP⁺ ← trans-dotriaconta-2-enoyl-CoA + NADPH + H⁺,
(13Z)-docosenoyl-CoA + NADP⁺ ← (2E,13Z)-docos-2,13-dienoyl-CoA + NADPH + H⁺,
(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + reduced two electron carrier → (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + oxidized electron carrier,
triacontanoyl-CoA + NADP⁺ ← trans-triaconta-2-enoyl-CoA + NADPH + H⁺,
adrenoyl-CoA + NADP⁺ ← (2E,7Z,10Z,13Z,16Z)-docosa-2,7,10,13,16-pentaenoyl-CoA + NADPH + H⁺,
trans-lesqueroloyl-CoA + NADPH + H⁺ → lesqueroloyl-CoA + NADP⁺,
hexatriacontanoyl-CoA + NADP⁺ ← trans-hexatriaconta-2-enoyl-CoA + NADPH + H⁺,
cerotoyl-CoA + NADP⁺ ← trans-cerot-2-enoyl-CoA + NADPH + H⁺,
(11Z,14Z,17Z)-icosatrienoyl-CoA + NAD⁺ ← (2E,11Z,14Z,17Z)-icosatetraenoyl-CoA + NADH + H⁺,
(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA + NADP⁺ ← (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NADPH + H⁺,
(2E,11Z)-icosa-2,11-dienoyl-CoA + NADPH + H⁺ → (cis)-gondoyl-CoA + NADP⁺

Enzymes and Genes:
very-long-chain enoyl-CoA reductase: TECR ( Homo sapiens )
very-long-chain enoyl-CoA reductase: TSC13 ( Saccharomyces cerevisiae )
very-long-chain enoyl-CoA reductase: CER10 ( Arabidopsis thaliana col )

Summary:
This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain fatty acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase.

Citations: [Kohlwein01, Gable04, Kvam05, Zheng05]

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References

Gable04: Gable K, Garton S, Napier JA, Dunn TM (2004). "Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system." J Exp Bot 55(396);543-5. PMID: 14673020

Kohlwein01: Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T (2001). "Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae." Mol Cell Biol 21(1);109-25. PMID: 11113186

Kvam05: Kvam E, Gable K, Dunn TM, Goldfarb DS (2005). "Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles." Mol Biol Cell 16(9);3987-98. PMID: 15958487

Zheng05: Zheng H, Rowland O, Kunst L (2005). "Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis." Plant Cell 17(5);1467-81. PMID: 15829606

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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