Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.2 -- Acting on the aldehyde or oxo group of donors → 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: 2-carboxybenzaldehyde dehydrogenase, 2CBAL dehydrogenase, PhdK

Systematic Name: 2-formylbenzoate:NAD⁺ oxidoreductase

Unification Links: BRENDA:1.2.1.78, ENZYME:1.2.1.78, IUBMB-ExplorEnz:1.2.1.78

Reaction:
2-formylbenzoate + NAD⁺ + H₂O = phthalate + NADH + 2 H⁺

Summary:
The enzyme is involved in phenanthrene degradation [Iwabuchi97, Kiyohara81].

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References

Iwabuchi97: Iwabuchi T, Harayama S (1997). "Biochemical and genetic characterization of 2-carboxybenzaldehyde dehydrogenase, an enzyme involved in phenanthrene degradation by Nocardioides sp. strain KP7." J Bacteriol 179(20);6488-94. PMID: 9335300

Kiyohara81: Kiyohara, H., Nagao, K., Yano, K. (1981). "Isolation and some properties of NAD-linked 2-carboxybenzaldehyde dehydrogenase in Alcaligenes faecalis AFK 2 grown on phenanthrene." J. Gen. Appl. Microbiol. 27:443-455.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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