Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.2 -- Acting on the aldehyde or oxo group of donors → 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: oxoglutarate dehydrogenase (NADP)

Systematic Name: 2-oxoglutarate:NADP⁺ 2-oxidoreductase (CoA-succinylating)

Unification Links: BRENDA:1.2.1.52, ENZYME:1.2.1.52, IUBMB-ExplorEnz:1.2.1.52

Reaction:
2-oxoglutarate + coenzyme A + NADP⁺ = succinyl-CoA + CO₂ + NADPH

Summary:
The Euglena enzyme can also use NAD⁺ as acceptor, but more slowly.

Citations: [Inui84]

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References

Inui84: Inui H, Miyatake K, Nakano Y, Kitaoka S (1984). "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis." J Biochem 96(3);931-4. PMID: 6438078

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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