Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.2 -- Acting on the aldehyde or oxo group of donors → 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: fatty acyl-CoA reductase

Systematic Name: hexadecanal:NAD⁺ oxidoreductase (CoA-acylating)

Unification Links: BRENDA:1.2.1.42, ENZYME:1.2.1.42, IUBMB-ExplorEnz:1.2.1.42

Reaction:
palmitoyl-CoA + NADH + H⁺ → hexadecanal + coenzyme A + NAD⁺

Unofficial Reactions:
hexadecanal + coenzyme A + NADP⁺ ← palmitoyl-CoA + NADPH + H⁺,
stearoyl-CoA + NADH + H⁺ → octadecanal + coenzyme A + NAD⁺

Summary:
Also acts, more slowly, on stearoyl-CoA.

Citations: [Johnson72]

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References

Johnson72: Johnson RC, Gilbertson JR (1972). "Isolation, characterization, and partial purification of a fatty acyl coenzyme A reductase from bovine cardiac muscle." J Biol Chem 247(21);6991-8. PMID: 4343165

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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