Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.14 -- Acting on paired donors, with incorporation or reduction of molecular oxygen → 1.14.15 -- With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

Synonyms: tylH1 (gene name)

Systematic Name: 20-oxo-5-O-β-mycaminosyltylactone,reduced ferredoxin:oxygen oxidoreductase (23-hydroxylating)

Unification Links: BRENDA:1.14.15.34, ENZYME:1.14.15.34, IUBMB-ExplorEnz:1.14.15.34

Supersedes EC number: 1.14.13.186

Reaction:
20-oxo-5-O-β-mycaminosyltylactone + 2 reduced ferredoxin [iron-sulfur] cluster + dioxygen + 2 H⁺ → 5-O-β-mycaminosyltylonolide + 2 oxidized ferredoxin [iron-sulfur] cluster + H₂O

Enzymes and Genes:
20-oxo-5-O-mycaminosyltylactone 23-monooxygenase: tylH1 ( Streptomyces fradiae )

Summary:
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.

Citations: [Baltz81, Reeves04]

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References

Baltz81: Baltz RH, Seno ET (1981). "Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin." Antimicrob Agents Chemother 20(2);214-25. PMID: 7283418

Reeves04: Reeves CD, Ward SL, Revill WP, Suzuki H, Marcus M, Petrakovsky OV, Marquez S, Fu H, Dong SD, Katz L (2004). "Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts." Chem Biol 11(10);1465-72. PMID: 15489173

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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