Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.14 -- Acting on paired donors, with incorporation or reduction of molecular oxygen → 1.14.14 -- With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Synonyms: anthranilate 3-hydroxylase, anthranilate hydroxylase

Systematic Name: anthranilate,FADH₂:oxygen oxidoreductase (3-hydroxylating)

Unification Links: BRENDA:1.14.14.8, ENZYME:1.14.14.8, IUBMB-ExplorEnz:1.14.14.8

Reaction:
anthranilate + FADH₂ + dioxygen → 3-hydroxyanthranilate + FAD + H⁺ + H₂O

Enzymes and Genes:
anthranilate hydroxylase: GTNG_3160 ( Geobacillus thermodenitrificans NG80-2 )

Summary:
This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and EC 1.5.1.45, FAD reductase [NAD(P)H], which ensures ample supply of FAD to the monooxygenase.

Citations: [Liu10a]

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References

Liu10a: Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L (2010). "Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2." Microbiology 156(Pt 2);589-95. PMID: 19942660

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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