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Synonyms: NspLOX, (9R)-LOX, linoleate 9R-dioxygenase

Systematic Name: α-linolenate:oxygen (9R)-oxidoreductase

Unification Links: BRENDA:1.13.11.61, ENZYME:1.13.11.61, IUBMB-ExplorEnz:1.13.11.61

Reaction:
α-linolenate + dioxygen → 9(R)-HpOTre

Unofficial Reactions:
arachidonate + dioxygen → (12R)-HpETE,
a ceramide EOS + dioxygen → a 9R-HPODE-esterified omega-hydroxyacyl-sphingosine,
an acylceramide + dioxygen → a (9R)-HPODE-acylceramide

Enzymes and Genes:
linolenate 9R-lipoxygenase: NspLOX ( Nostoc sp. PCC 7120 = FACHB-418 )

Summary:
In cyanobacteria the enzyme is involved in oxylipin biosynthesis. The enzyme also converts linoleate to (9R)-HPODE.

Citations: [Andreou08, Lang08, Jerneren10]

References

Andreou08: Andreou AZ, Vanko M, Bezakova L, Feussner I (2008). "Properties of a mini 9R-lipoxygenase from Nostoc sp. PCC 7120 and its mutant forms." Phytochemistry 69(9);1832-7. PMID: 18439634

Jerneren10: Jerneren F, Hoffmann I, Oliw EH (2010). "Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus." Arch Biochem Biophys 495(1);67-73. PMID: 20043865

Lang08: Lang I, Gobel C, Porzel A, Heilmann I, Feussner I (2008). "A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120." Biochem J 410(2);347-57. PMID: 18031288