Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: L-aminopropanol dehydrogenase, 1-aminopropan-2-ol-NAD⁺ dehydrogenase, L(+)-1-aminopropan-2-ol:NAD⁺ oxidoreductase, 1-aminopropan-2-ol-dehydrogenase, DL-1-aminopropan-2-ol: NAD⁺ dehydrogenase, L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase

Systematic Name: (R)-1-aminopropan-2-ol:NAD⁺ oxidoreductase

Unification Links: BRENDA:1.1.1.75, ENZYME:1.1.1.75, IUBMB-ExplorEnz:1.1.1.75

Reaction:
(R)-1-aminopropan-2-ol + NAD⁺ ← aminoacetone + NADH + H⁺

Enzymes and Genes:
L-1,2-propanediol dehydrogenase / glycerol dehydrogenase: gldA ( Escherichia coli K-12 substr. MG1655 )

Summary:
Requires K⁺.

Citations: [Tuner66, Turner67, Dekker68]

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References

Dekker68: Dekker EE, Swain RR (1968). "Formation of Dg-1-amino-2-propanol by a highly purified enzyme from Escherichia coli." Biochim Biophys Acta 158(2);306-7. PMID: 4385233

Tuner66: Tuner JM (1966). "Microbial metabolism of amino ketones. Aminoacetone formation from 1-aminopropan-2-ol by a dehydrgenase in Escerichia coli." Biochem J 99(2);427-33. PMID: 5329339

Turner67: Turner JM (1967). "Microbial metabolism of amino ketones. L-1-aminopropan-2-ol dehydrogenase and L-threonine dehydrogenase in Escherichia coli." Biochem J 104(1);112-21. PMID: 5340733

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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