Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: D-mannitol dehydrogenase, mannitol dehydrogenase

Systematic Name: D-mannitol:NAD⁺ 2-oxidoreductase

Unification Links: BRENDA:1.1.1.67, ENZYME:1.1.1.67, IUBMB-ExplorEnz:1.1.1.67

Reaction:
NAD⁺ + D-mannitol ↔ keto-D-fructose + NADH + H⁺

Unofficial Reactions:
NAD⁺ + D-sorbitol ↔ keto-L-sorbose + NADH + H⁺

Enzymes and Genes:
D-mannitol 2-dehydrogenase: lxr1 ( Trichoderma reesei )
D-mannitol 2-dehydrogenase ( Eimeria tenella )
D-arabinitol 4-dehydrogenase/mannitol 2-dehydrogenase: mtlD ( Pseudomonas fluorescens )

Citations: [Martinez63]

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References

Martinez63: Martinez, G., Barker, H.A., Horecker, B.L. (1963). "A specific mannitol dehydrogenase from Lactobacillus brevis." J. Biol. Chem. 238: 1598–1603.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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