Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Systematic Name: 2-dehydro-3-deoxy-L-fuconate:NAD⁺ 4-oxidoreductase

Unification Links: BRENDA:1.1.1.434, ENZYME:1.1.1.434, IUBMB-ExplorEnz:1.1.1.434

Reaction:
2-dehydro-3-deoxy-L-fuconate + NAD⁺ → 2,4-didehydro-3-deoxy-L-fuconate + NADH + H⁺

Unofficial Reactions:
2-dehydro-3-deoxy-D-pentonate + NAD⁺ → 5-hydroxy-2,4-dioxopentanoate + NADH + H⁺

Enzymes and Genes:
2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase: XCC4067 ( Xanthomonas campestris pv. campestris )
2-dehydro-3-deoxy-D-pentonate/2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase: C785_RS13675 ( Herbaspirillum huttiense )

Summary:
The enzyme, originally described from the bacterium Xanthomonas campestris pv. campestris, participates in an L-fucose degradation pathway. It can also act on 2-dehydro-3-deoxy-L-galactonate and 2-dehydro-3-deoxy-D-pentonate.

Citations: [Yew06, Watanabe19]

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References

Watanabe19: Watanabe S, Fukumori F, Nishiwaki H, Sakurai Y, Tajima K, Watanabe Y (2019). "Novel non-phosphorylative pathway of pentose metabolism from bacteria." Sci Rep 9(1);155. PMID: 30655589

Yew06: Yew WS, Fedorov AA, Fedorov EV, Rakus JF, Pierce RW, Almo SC, Gerlt JA (2006). "Evolution of enzymatic activities in the enolase superfamily: L-fuconate dehydratase from Xanthomonas campestris." Biochemistry 45(49);14582-97. PMID: 17144652

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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