Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: gld1 (gene name), gaaD (gene name)

Systematic Name: glycerol:NADP⁺ oxidoreductase (D/L-glyceraldehyde-forming)

Unification Links: BRENDA:1.1.1.372, ENZYME:1.1.1.372, IUBMB-ExplorEnz:1.1.1.372

Reaction:
glycerol + NADP⁺ ← L-glyceraldehyde + NADPH + H⁺,
glycerol + NADP⁺ ↔ D-glyceraldehyde + NADPH + H⁺

Enzymes and Genes:
D-glyceraldehyde reductase / L-glyceraldehyde reductase: GLD1 ( Trichoderma reesei )

Summary:
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei. It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.

Citations: [Liepins06, MartensUzunova08]

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References

Liepins06: Liepins J, Kuorelahti S, Penttila M, Richard P (2006). "Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina." FEBS J 273(18);4229-35. PMID: 16930134

MartensUzunova08: Martens-Uzunova ES, Schaap PJ (2008). "An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation." Fungal Genet Biol 45(11);1449-57. PMID: 18768163

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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