Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: aflD (gene name), nor-1 (gene name)

Systematic Name: (1′S)-averantin:NADP⁺ oxidoreductase

Unification Links: BRENDA:1.1.1.349, ENZYME:1.1.1.349, IUBMB-ExplorEnz:1.1.1.349

Reaction:
(1'S)-averantin + NADP⁺ ↔ norsolorinate + NADPH + H⁺

Enzymes and Genes:
norsolorinate ketoreductase: aflD ( Aspergillus parasiticus )

Summary:
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.

Citations: [Yabe93, Zhou99]

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References

Yabe93: Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T (1993). "Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin." Appl Environ Microbiol 59(8);2486-92. PMID: 8368836

Zhou99: Zhou R, Linz JE (1999). "Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus." Appl Environ Microbiol 65(12);5639-41. PMID: 10584035

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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