| Parent Class: | EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor |
Synonyms: 3α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (A-specific), 3α-hydroxysteroid 3-dehydrogenase (A-specific)
Systematic Name: 3α-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Re-specific)
Unification Links: BRENDA:1.1.1.213, ENZYME:1.1.1.213, IUBMB-ExplorEnz:1.1.1.213
Reaction:
a 3α-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+
Unofficial Reactions:
5β-cholestane-3α,7α-diol + NAD(P)+ ← 7α-hydroxy-5β-cholestan-3-one + NAD(P)H + H+,
5-α-androstan-3α,17β-diol + NAD(P)+ ↔ 5α-dihydrotestosterone + NAD(P)H + H+,
17-hydroxybrexanolone + NAD(P)+ ← 5α-pregnan-17α-3,20-dione-17-ol + NAD(P)H + H+,
5β-cholestane-3α,7α,12α-triol + NAD(P)+ ← 7α,12α-dihydroxy-5β-cholestan-3-one + NAD(P)H + H+,
androsterone + NAD(P)+ ↔ 5α-androstanedione + NAD(P)H + H+,
5-α-androstan-3α,17β-diol + NADP+ → 5α-dihydrotestosterone + NADPH + H+,
allopregnanolone + NAD(P)+ ← 5α-dihydroprogesterone + NAD(P)H + H+
Enzymes and Genes:
aldo-keto reductase family 1 member C4:
AKR1C4 (
Homo sapiens
)
3α hydroxysteroid dehydrogenase III:
AKR1C2 (
Homo sapiens
)
Summary:
The enzyme acts on multiple 3α-hydroxysteroids. Re-specific with respect to NAD+ or NADP+. cf.
EC 1.1.1.50, 3α-hydroxysteroid 3-dehydrogenase (Si-specific). Enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known are described by
EC 1.1.1.357, 3α-hydroxysteroid 3-dehydrogenase.
Citations: [Tonkins56, Bjorkhem70]
References
Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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