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Homo sapiens Reaction: 3.1.1.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.1.5

Enzymes and Genes:
Calcium-independent phospholipase A2-gamma : PNPLA8
Neuropathy target esterase : PNPLA6
Lysophospholipase : PLB1
Eosinophil lysophospholipase : CLC
Galactoside-binding soluble lectin 13 : LGALS13
Group XV phospholipase A2 : PLA2G15
Acyl-protein thioesterase 1 : LYPLA1
Lysophospholipase : PLA2G4A
Acyl-protein thioesterase 2 : LYPLA2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: lysophospholipase

Enzyme Commission Synonyms: lecithinase B, lysolecithinase, phospholipase B, lysophosphatidase, lecitholipase, phosphatidase B, lysophosphatidylcholine hydrolase, lysophospholipase A1, lysophopholipase L2, lysophospholipase transacylase, neuropathy target esterase, NTE, NTE-LysoPLA, NTE-lysophospholipase

Citations: [vanTienhoven02, vandenBosch81, vandenBosch73, Shapiro53, Dawson58, Quistad03, Lush98, Winrow03]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:3.1.1.5 , ENZYME:EC:3.1.1.5 , IUBMB-ExplorEnz:EC:3.1.1.5


References

Dawson58: Dawson RM (1958). "Studies on the hydrolysis of lecithin by a Penicillium notatum phospholipase B preparation." Biochem J 70(4);559-70. PMID: 13607409

Lush98: Lush MJ, Li Y, Read DJ, Willis AC, Glynn P (1998). "Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man." Biochem J 332 ( Pt 1);1-4. PMID: 9576844

Quistad03: Quistad GB, Barlow C, Winrow CJ, Sparks SE, Casida JE (2003). "Evidence that mouse brain neuropathy target esterase is a lysophospholipase." Proc Natl Acad Sci U S A 100(13);7983-7. PMID: 12805562

Shapiro53: Shapiro B (1953). "Purification and properties of a lysolecithinase from pancreas." Biochem J 53(4);663-6. PMID: 13032127

vandenBosch73: van den Bosch H, Aarsman AJ, de Jong JG, van Deenem LL (1973). "Studies on lysophospholipases. I. Purification and some properties of a lysophospholipase from beef pancreas." Biochim Biophys Acta 296(1);94-104. PMID: 4693514

vandenBosch81: van den Bosch H, Vianen GM, van Heusden GP (1981). "Lysophospholipase--transacylase from rat lung." Methods Enzymol 71 Pt C;513-21. PMID: 7278668

vanTienhoven02: van Tienhoven M, Atkins J, Li Y, Glynn P (2002). "Human neuropathy target esterase catalyzes hydrolysis of membrane lipids." J Biol Chem 277(23);20942-8. PMID: 11927584

Winrow03: Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE, Barlow C (2003). "Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity." Nat Genet 33(4);477-85. PMID: 12640454


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Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 19.0 on Thu Jul 30, 2015, biocyc11.