Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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Homo sapiens Reaction: 3.1.1.5

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.1.5

Enzymes and Genes:
Calcium-independent phospholipase A2-gamma : PNPLA8
Neuropathy target esterase : PNPLA6
Lysophospholipase : PLB1
Eosinophil lysophospholipase : CLC
Galactoside-binding soluble lectin 13 : LGALS13
Group XV phospholipase A2 : PLA2G15
Acyl-protein thioesterase 1 : LYPLA1
Lysophospholipase : PLA2G4A
Acyl-protein thioesterase 2 : LYPLA2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: lysophospholipase

Enzyme Commission Synonyms: lecithinase B, lysolecithinase, phospholipase B, lysophosphatidase, lecitholipase, phosphatidase B, lysophosphatidylcholine hydrolase, lysophospholipase A1, lysophopholipase L2, lysophospholipase transacylase, neuropathy target esterase, NTE, NTE-LysoPLA, NTE-lysophospholipase

Citations: [vanTienhoven02, vandenBosch81, vandenBosch73, SHAPIRO53, DAWSON58, Quistad03, Lush98, Winrow03]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:3.1.1.5 , ENZYME:EC:3.1.1.5 , IUBMB-ExplorEnz:EC:3.1.1.5


References

DAWSON58: DAWSON RM (1958). "Studies on the hydrolysis of lecithin by a Penicillium notatum phospholipase B preparation." Biochem J 70(4);559-70. PMID: 13607409

Lush98: Lush MJ, Li Y, Read DJ, Willis AC, Glynn P (1998). "Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man." Biochem J 332 ( Pt 1);1-4. PMID: 9576844

Quistad03: Quistad GB, Barlow C, Winrow CJ, Sparks SE, Casida JE (2003). "Evidence that mouse brain neuropathy target esterase is a lysophospholipase." Proc Natl Acad Sci U S A 100(13);7983-7. PMID: 12805562

SHAPIRO53: SHAPIRO B (1953). "Purification and properties of a lysolecithinase from pancreas." Biochem J 53(4);663-6. PMID: 13032127

vandenBosch73: van den Bosch H, Aarsman AJ, de Jong JG, van Deenem LL (1973). "Studies on lysophospholipases. I. Purification and some properties of a lysophospholipase from beef pancreas." Biochim Biophys Acta 296(1);94-104. PMID: 4693514

vandenBosch81: van den Bosch H, Vianen GM, van Heusden GP (1981). "Lysophospholipase--transacylase from rat lung." Methods Enzymol 71 Pt C;513-21. PMID: 7278668

vanTienhoven02: van Tienhoven M, Atkins J, Li Y, Glynn P (2002). "Human neuropathy target esterase catalyzes hydrolysis of membrane lipids." J Biol Chem 277(23);20942-8. PMID: 11927584

Winrow03: Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE, Barlow C (2003). "Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity." Nat Genet 33(4);477-85. PMID: 12640454


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of HumanCyc: Genome Biology 6(1):1-17 2004
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc11.